1/ I disapprove;
2/ You've been naughty;
3/ What a shame;
4/ How embarrassing for you;
5/ Isn't life unfair sometimes!
6/ I
commiserate with your sadness/suffering/ill treatment.
Sometimes represented as Tch Tch or
Tut Tut, Tsk is more a vocal sound than an actual word, and "pronounced" by forming a T-sound, but then sucking lightly on the palate. People only say "
Tisk tisk" as a parody of the actual sound, making fun of the act of disapproval or shaming.